Individual Differences in Conditioned Pain Modulation are Associated with Static Functional Connectivity Within the Descending Antinociceptive Pathway
Bibliographic record
Abstract
This thesis aimed to determine whether an individual’s capacity to exhibit conditioned pain modulation (CPM) (changes in test stimuli (TS) pain due to a conditioning stimulus (CS)) reflects static functional connectivity (FC) of the descending antinociceptive pathway (DAP) in 151 healthy participants (72 males, 79 females). Three types of CPM effect were identified: 1) Antinociception: TS pain attenuated (38% of participants), 2) No-CPM: no significant change in TS (32% of participants), and 3) Pronociception: increased TS pain (30% of participants). Resting-state functional MRI was used to determine FC between the subgenual anterior cingulate cortex (sgACC), periaqueductal gray (PAG), and rostroventral medulla (RVM). The correlation of sgACC - RVM FC had a medium effect size with CPM effect magnitude in the CPM/Antinociception group. Females, compared to males, were more likely to be categorized as Pronociceptive. This thesis suggests that FC of the DAP may reflect or contribute to CPM.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".