The Role of Extrinsic Connections and Stimulus Identity in Ventral Hippocampus Mediated Approach-Avoidance Conflict Resolution
Bibliographic record
Abstract
The ventral hippocampus (HPC) has is a key mediator of approach-avoidance conflict, which occurs when organisms are confronted with a stimulus associated with opposing valences. Surprising findings have emerged regarding how different ventral HPC subregions mediate conflict resolution, and additionally suggest that only certain conflict conditions elicit ventral HPC activity. This thesis set out to investigate the role of the ventral HPC subregions and their extrinsic connections in approach-avoidance conflict, the conditions in which they are necessary for conflict mediation, and the extent to which established pathways that mediate conflict in rodents generalize to humans.The first experiment utilized established mixed valence Y-maze and metric pattern discrimination paradigms to investigate the extent to which the ventral and dorsal dentate gyrus (vDG and dDG) mediate approach-avoidance conflict and spatial pattern separation, respectively. These experiments revealed a double dissociation, with pharmacological inhibition of the vDG leading to conflict approach responses, while inhibition of the dDG impaired metric pattern discrimination. The second study investigated the extent to which conflict scenarios with simple light/sound cue signaled outcomes are mediated by the ventral HPC. Chemogenetic inhibition of the ventral HPC led to no alterations in response to conflict in either reinforced or non-reinforced conditions, suggesting that sufficiently simple conflict conditions do not require ventral HPC activity. The third investigation examined the role extrinsic connections from the ventral CA3 and CA1 (vCA3 and vCA1) to the lateral septum (LS) play in approach-avoidance conflict. It was found that chemogenetic inhibition of the vCA3 to caudodorsal LS pathway released approach responses to conflict stimuli, while inhibition of vCA1 to rostroventral LS pathway led to non-specific behavioural disinhibition. The fourth investigation used human functional magnetic resonance imaging data to examine the correlations between the human HPC, LS, and hypothalamus at rest. This found that activity between these 3 regions are correlated, and the details of these connections suggest a continuity of pathways responsible for conflict mediation between species. Together, these results reveal that the ventral HPC subfields contain multiple pathways that mediate approach-avoidance conflict elicited under complex conditions and suggest that these pathways are preserved in humans.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".