Deuterium Magnetic Resonance Spectroscopy of Early Treatment-induced Changes in Tumour Lactate
Bibliographic record
Abstract
An emerging hallmark of many tumour cells is aberrant metabolism, characterized in part by elevated lactate production. In response to treatment, tumour cells exhibit a change in lactate production that precedes late-stage morphological measurements conventionally used to assess tumour response. These metabolic changes can be non-invasively measured by Deuterium (2H) Magnetic Resonance Spectroscopy (MRS), but there has been limited work exploring the feasibility of using 2H-lactate as a marker of early tumour response to treatment. In this thesis, the biological processes associated with treatment-induced changes in the 2H-lactate signal were established in an in vitro tumour model. Significant decreases in 2H-lactate were observed 48 hours after treatment with a chemotherapeutic agent and associated with apoptotic cell death and decreased extracellular lactate. These findings offer the opportunity to build a framework for preclinical 2H MRS studies of tumour metabolism, with the goal of enhancing assessment of tumour response in the clinic.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".