The role of activated Ras in the regulation of neural precursors
Bibliographic record
Abstract
The objective of this thesis is to determine how alterations in Ras proto-oncogene activity perturb the function of neural precursor cells in the central nervous system. Among the consequences of germline mutations that constitutively activate Ras are malignant astrocytomas and the neuro-cardio-facial-cuteanous (NCFC) syndromes, which feature developmental abnormalities including mental retardation. Since both tumors and cognitive changes are observed in children with activated Ras mutations, I hypothesize that one of the cell types targeted by increased Ras activity is the neural precursor cell responsible for generating neurons and glia. In this thesis, I have found that constitutively activated Ras in cortical precursors induces proliferation and the preferential genesis of astrocytes at the expense of neurons. The Ras-induced proliferation of precursors and astrocytes may represent an initial step in the development of astrocytomas, and the perturbations of cell genesis may be a contributing factor to cognitive impairments seen in NCFC syndromes.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".