An Evaluation of Treatment Response and Clinical Event-free Survival in Autoimmune Hepatitis: A Canadian Multicentre Cohort Analysis
Bibliographic record
Abstract
Autoimmune hepatitis (AIH) is a rare immune-mediated inflammatory liver disease, that if left untreated, can progress to liver decompensation, liver transplantation, or death. Alanine aminotransferase (ALT) is a surrogate marker of treatment response and serves as an indicator of disease activity. The first study examined the prognostic factors that were associated with ALT improvements during the first 18 months of treatment. This study found that older age was associated with improvement in ALT at 6 and 12 months, whereas baseline biochemistry, cirrhosis status, and medication dose did not significantly impact ALT over time. The second study investigated the association of dynamic biochemical patterns overtime on the risk of experiencing a liver-related clinical event. This study showed that continuous elevations in liver transaminase, but not immunoglobulin G, were associated with an increased risk of experiencing a liver decompensation event, liver transplantation, or death.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.007 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.003 |
| Bibliometrics | 0.002 | 0.004 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".