Ibutilide as a firstline antiarrhythmic drug in a porcine model of out-of-hospital cardiac arrest
Bibliographic record
Abstract
Results and Conclusions. Ibutilide increased DFT (161.1 +/- 33.3 J vs. 200 +/- 54.8 J, p = 0.044). Ibutilide did not significantly change any other variable measured. The ITV did not significantly change any variable measured. Ibutilide appears inactive in the pig, while the ITV may not function properly when used with automatic ventilators. Objectives. Class III antiarrhythmics have been demonstrated to lower defibrillation threshold (DFT). The impedance threshold valve (ITV) has been demonstrated to improve hemodynamics during cardiopulmonary resuscitation (CPR). We hypothesize that administration of the class III antiarrhythmic drug ibutilide, and use of the ITV during CPR after induction of ventricular fibrillation (VF) will lead to greater short-term survival vs. control. Methods. VF was induced in 30--35 kg pigs and left untreated for 4 minutes. CPR was performed for 8 minutes using automatic ventilation. 0.005 mg/kg IV ibutilide was administered during CPR. Electrophysiologic and hemodynamic variables were measured at baseline, during CPR, and post-resuscitation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".