Can IgG autoantibodies against beta2GPI complexed with oxidized low-density lipoprotein be a marker of arterial thrombosis in anti-phospholipid syndrome patients?
Bibliographic record
Abstract
Background. Atherogenesis invokes an immune response involving mediators of innate and acquired immunity. APL has been proposed to promote thrombosis by involving cellular effects, plasma coagulation regulatory proteins, and fibrinolysis. The presence of APL antibodies in serum is associated with arterial and venous thrombosis and recurrent pregnancy loss, but the pathogenic mechanisms mediating these events are unknown. Anti-beta2GPI/oxLig-1 has been associated with arterial thrombosis in anti-phospholipid syndrome patients. Objectives. To study the relationship of IgM/IgG autoantibodies against oxLDL/beta2GPI and beta2GPI with the clinical manifestations of anti-phospholipid syndrome and systemic lupus erythematosus in 3 major cohorts in Canada. Methods. A cross-sectional study of anti-beta2GPI/oxLig-1 and anti-beta2GP1 was performed on the first sample that was available in 3 cohorts of patients. The 3 cohorts had 863 patients in total who had at least one serum sample available. A random sample (n=402) was drawn according to APL status and thromboembolic events. The study sample was divided into 4 populations: (1) aPL-positive patients with thromboembolic events, (2) aPL-positive patients without thromboembolic events, (3) aPL-negative patients with thromboembolic events, and (4) aPL-negative patients without thromboembolic events. Results. Each group had 84, 84, 115, and 119 patients, respectively. The average age was 47.8, 48.2, 49, and 41.6 years, respectively. Each group was 81.2%, 89.3%, 79.8%, and 89.1% female, respectively. There was no statistically significant difference between serum levels of IgM/IgG anti-beta2GPI/oxLig-1 antibodies in patients with no thromboembolic events, compared with arterial events only (p=0.41) and venous events only (p=0.21). IgG anti-beta2GPI was significantly higher in patients with arterial thrombosis (67%) (p=0.02) compared with those who did not have a history of arterial thrombosis (51%). Advance age, hypertension, and IgG anti-beta2GPI antibody were risk factors for arterial thrombosis, by multivariate analysis. Conclusions. Anti-beta2GPI/oxLig-1 levels were not significantly different between APS patients with a history of arterial thrombosis events and those with no history of arterial thrombosis. IgG anti-beta2GPI antibody is significantly higher in APS patients with a history of arterial thrombosis. This relation remained significant on multivariate analysis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".