Staphanofilarial dermatitis (humpsore) treatment trial in Tashicholing, Samtse District
Bibliographic record
Abstract
Humpsore is askin disease incattlecaused by a vector borne nematode belonging to the genus, Staphanofilaria. To select a treatment optionwith the highest sore recovery rate,a treatment trial was conducted in four villages under Tashicholing Drungkhag, Samtseinvolving 80 humpsore affected animals.These animals were randomly assigned to four groups namely: 1) group1 (single ivermectin injection sub-cutaneously @ 1ml/50 kgbody weight + topical application of Zinc Oxide (ZnO) ointment daily); 2) group2 (single levamisole HCl injection sub-cutaneously @ 1ml/50 kgbody weightt + topical application of Zinc Oxide (ZnO) ointment daily); 3) group3 (Topical application of Zinc Oxide (ZnO) ointment daily);and group 4 (untreated control). ZnOointmentwas applied dailyfor the entiretrial period. Ivermectin and Levamisole injection was given on the second day of the trial. The sore size(in cm)was measured before application of any treatment and thereafter on weekly interval. The change in mean sore size for each group was computed using a one sample t-test while the comparison between group was made using one-way ANOVAand pair-wise t-test. In total 24 deep lesionscrapingswere collected from the animals that were enrolled inthe trial as well as from those which were not. Samples wereprocessed using conventional sedimentation method and the Baermann’ technique for recovery of the parasite. Bythe end of the trial, complete healing of the lesion was observed in 14 (70%) animals under group1, 12 (60%) under group2 and 13 (62%) under group3. Analysis showed that the reduction in the mean sore size for all the groupwas statistically significant (p<0.0001) except for the control group (p=0.06). There was no statistically significant difference in the mean sore size between the groups before the start of the trial (p=0.24). By the third week, the difference in the mean sore size for all the treatment groups, group1 (p<0.0001), group2 (p<0.001) and groupthree (p<0.0001) was statistically significantdifferencefrom the control group. Microfilaria was isolated in 9 of the 24 samples with a microfilaria recovery rate of 37.5%. This study has further validated that ivermectin injection @ 1 ml/50kg body weight with topical application of zinc oxide ointment for three weeks has the highest efficacy against humpsore. Italso proposesa speculation, for further validation, that isolating active microfilaria is more likely in samples that are collected in the later part of the day.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".