Bibliographic record
Abstract
Two forms of GABAergic inhibition exist in the brain: a persistent tonic and transient synaptic inhibition. Mammalian GABAA receptors are hetero-pentameric, ligand-gated, chloride channels assembled from a family of ge;19 related subunits. To test the hypothesis that tonic current in CA1 hippocampal pyramidal neurons is mediated by alpha5 subunit-containing GABA A receptors, we used an assortment of subunit-selective drugs. Previously, we showed that classical benzodiazepines enhance the tonic current. Here, we show that tonic conductance is modulated by the alpha5-selective negative modulator L-655,708 but not by the alpha5-sparing imidazopyridine, zolpidem. Moreover, beta2/3-selective positive allosteric modulators enhance the tonic current where delta-sensitive neurosteroids do not, suggesting that the alpha5 subunit assembles with beta2/3 and gamma subunits to form tonic GABA A receptor complexes in the hippocampus. Deletion of the alpha5 subunit results in a 75% reduction in tonic current. Thus, we attribute tonic inhibition in hippocampal pyramidal neurons to alpha5-containing GABA A receptors.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".