Bibliographic record
Abstract
Closed-Loop Neuromodulation (CLN) is a form of adaptive therapy that provides stimulation only when necessary. Clinical trials have shown that, despite several advantages, fundamental insights in pathological state-classification and stimulus application are still needed to realize the full potential of CLN. However, the existing research tools have functional limitations or proprietary restrictions that hinder exploration of state-classification algorithms and stimulation protocols. This thesis presents the design of a digital hardware platform to address these issues. The platform interfaces with neural sensors and enables the development of custom software and firmware for the evaluation of complex algorithms and low-latency applications. In addition, the incorporation of a Python-based hardware description language and partial reconfiguration facilitates the creation of a reusable firmware library for CLN research. An in vitro electrophysiological system using multielectrode arrays and an in vivo multimodal system with an implantable opto-electrode are implemented to demonstrate the capability of the platform.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.025 | 0.010 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".