Paediatric Crohn's Disease: The Impact of First Maintenance Therapy
Bibliographic record
Abstract
Background: Tumour necrosis factor-a antagonist (aTNF) therapy is increasingly used as primary therapy to induce and/or maintain remission of Crohn’s disease (CD). Aim: This study compared outcomes with immunomodulator (IM) versus aTNF-based first maintenance therapy in paediatric CD. Methods: This study analyzed data from the Canadian Children IBD Network (CIDsCaNN) inception cohort study. Children with newly diagnosed luminal inflammatory CD receiving IM or aTNF-based first maintenance therapy were included in this analysis. The primary outcome was 18-month sustained steroid-free clinical remission and intestinal healing on first maintenance therapy. Propensity score matching was used to match children on baseline characteristics who received aTNF therapy or IM as first maintenance. Results: The primary outcome was more often met with aTNF vs IM maintenance. Conclusion: aTNF was superior to IM as first maintenance therapy in paediatric luminal CD. This was true even before matching, despite greater CD activity among children receiving aTNF therapy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.009 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".