Dissecting the Roles of Anillin's Interaction with Importin Beta 2 and mDia2
Bibliographic record
Abstract
Successful completion of cytokinesis, the final step of cell division, is required to prevent aneuploidy. A vital step in cytokinesis is the formation of an actomyosin ring. Actin filament formation and contraction is key to the ingression of the ring, but the mechanism still remains unclear. Anillin is a scaffolding protein able to cross-link actin with other cytoskeletal elements and regulatory factors of the ring. I sought to examine the roles of the interactions mediated by anillin in cytokinesis. I identified a novel anillin-importin beta 2 interaction which targets anillin to the nucleus and regulates cell shape in interphase. More importantly, I identified a mechanism by which anillin enhances RhoA dependent activation of formin mDia2. My data suggest a new model whereby anillin acts as an enhancer to help RhoA to fully activate mDia to effectively function in regulating actin organization during ring ingression.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".