The Role of Branched Chain Fatty Acids in Cardiometabolic Disorders Underlying Type 2 Diabetes in the PROMISE Cohort
Bibliographic record
Abstract
Various fatty acids are linked with risk of type 2 diabetes (T2DM), although the branched chain fatty acids (BCFA) are under-investigated. This thesis aimed to (1) systematically review the available literature on the association of BCFAs with cardiometabolic disorders; and (2) investigate the relationship of BCFAs across 4 serum fractions with dietary intake and analyze the longitudinal association between BCFAs and pathophysiological disorders underlying T2DM. Three of the 4 studies identified in our review reported significant inverse associations between circulating BCFAs/monomethyl BCFAs and insulin sensitivity. Correlations between total dairy and BCFAs showcased pool specific results. Our longitudinal analysis documented heterogenous results that were largely modest in magnitude and significance. Most notably, iso15:0 and anteiso15:0 (NEFA) were positively associated with measures of insulin sensitivity while iso14:0 and anteiso14:0 (NEFA) were inversely associated with the same measures. Our findings highlight the need for additional research on BCFAs and their role in cardiometabolic outcomes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".