The effect of pulmonary edema fluid on ion transport by adult alveolar type II epithelial cells
Bibliographic record
Abstract
Previous studies show cardiogenic edema fluid (EF) increases in vitro Na+ transport by fetal distal lung epithelia (FDLE) (J. Physiol, 2002). The present study investigates the effect of EF on Na+ and fluid transport in the adult lung. EF-treated primary cultures of alveolar type II (ATII) epithelium had a dose-dependent increase in amiloride-insensitive Na+ transport. Treatment of ATII with high or low doses of EF did not alter amiloride-sensitive Na+ transport; however, moderate doses increased it. Plasma did not have a similar effect. Globulins-treated cells demonstrated a conversion of amiloride-sensitive to amiloride-insensitive current without increasing total current. Changes in ENaC mRNA levels did not always parallel changes in treatment-induced bioelectric properties. We conclude that cardiogenic EF increases ion transport by ATII, predominately via increased amiloride-insensitive Isc. These studies point towards new therapeutic approaches for patients with congestive heart failure or adult respiratory distress syndrome-induced pulmonary edema.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".