The effect of pulmonary edema fluid on ion transport by adult alveolar type II epithelial cells
Bibliographic record
Abstract
Previous studies show cardiogenic edema fluid (EF) increases in vitro Na+ transport by fetal distal lung epithelia (FDLE) (J. Physiol, 2002). The present study investigates the effect of EF on Na+ and fluid transport in the adult lung. EF-treated primary cultures of alveolar type II (ATII) epithelium had a dose-dependent increase in amiloride-insensitive Na+ transport. Treatment of ATII with high or low doses of EF did not alter amiloride-sensitive Na+ transport; however, moderate doses increased it. Plasma did not have a similar effect. Globulins-treated cells demonstrated a conversion of amiloride-sensitive to amiloride-insensitive current without increasing total current. Changes in ENaC mRNA levels did not always parallel changes in treatment-induced bioelectric properties. We conclude that cardiogenic EF increases ion transport by ATII, predominately via increased amiloride-insensitive Isc. These studies point towards new therapeutic approaches for patients with congestive heart failure or adult respiratory distress syndrome-induced pulmonary edema.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".