Effects of repeated antenatal dexamethasone (dex) exposure on hypothalamic-pituitary-adrenal (HPA) function in mature adult guinea pigs (Cavis porcellus)
Bibliographic record
Abstract
We examined the effects of antenatal glucocorticoid treatment on mature adult hypothalamic-pituitary-adrenal (HPA) function in guinea pigs. Pregnant guinea pigs were treated with dexamethasone or vehicle on days 40/41, 50/51 and 60/61 of gestation, after which animals delivered normally. Offspring were catheterized at 145 days of age and subjected to tests of HPA axis function. Male offspring exposed to dexamethasone in utero exhibited decreased basal cortisol, increased HPA sensitivity to challenge, increased hippocampus to brain weight ratio, increased adrenal to body weight ratio and increased mean arterial pressure. Female offspring born to dex-treated mothers showed a significant increase in basal cortisol during the low progesterone phase and an increase in HPA sensitivity irrespective of progesterone. Changes in endocrine data were consistent with changes in mineralocorticoid receptor in the limbic system and glucocorticoid receptor in the pituitary. In conclusion, repeated antenatal glucocorticoid exposure permanently modifies offspring HPA function in sex-specific manner.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".