Bibliographic record
Abstract
High-protein feeding stimulates gut hormone release and improves glucose control. The site of action, however, remains uncertain. Interestingly, gut protein infusion increases hormone secretion, but whether gut protein sensing mechanisms regulate glucose homeostasis remains controversial. In this thesis, I found that upper small intestinal (USI, targeting the lower duodenum and upper jejunum) infusion of casein hydrolysate increased intravenous glucose tolerance in chow-fed rats, which was reversed by USI-specific chemical and genetic inhibition of the calcium-sensing receptor (CaSR). This glucoregulatory pathway remained intact after short-term high-fat (HF)-feeding in association with increased USI CaSR expression. In parallel, ileal casein infusion increased glucose tolerance in chow-fed rats via CaSR. However, HF feeding reduced ileal CaSR—contrasting the stimulatory effect in the USI—while ileal casein action on glucose tolerance remained intact independent of CaSR. My thesis highlights novel gut protein sensing mechanisms that regulate glucose homeostasis through CaSR dependency and independency
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".