Three-dimensional Assembly and Characterization of Protein-based Tubular Constructs for Tissue Engineering
Bibliographic record
Abstract
In this thesis I present a strategy for rolling highly aligned collagen sheets into tubular constructs which have applications as implantable bile duct grafts or in organ-on-a-chip systems. Aligned collagen sheets were extruded through a microfluidic device following a previously described protocol, and vertically stacked to achieve suitable mechanical properties for rolling. A rolling process was developed, characterized, and optimized for rolling tubular structures with a 700 μm inner diameter and 50 μm wall thickness, mimicking the dimensions of rat bile ducts. Rolled tubes were mechanically characterized for suture retention strength and burst pressure. The mechanism of failure in these tests was also investigated, providing insights for methods to further increase mechanical properties. Cholangiocyte precursors and cholangiocyte cysts were loaded into tubes in a custom-made tube hosting device and appeared to attach, spread, and remain viable up to 9 days in culture.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".