Infant Nasal Microbiome and Respiratory Health Outcomes in Early Childhood in the CHILD Cohort
Bibliographic record
Abstract
The microbes that reside on the surface of our nose and sinuses make up the nasal microbiome. Using the data from the CHILD Cohort Study, a large Canadian prospective longitudinal cohort, we sampled the nasal microbiome and examined which environmental factors were associated with nasal microbiome alpha diversity and differential abundance, the effects ofviral presence on the nasal microbiome and if the nasal microbiome was associated with early life respiratory disease (asthma, wheeze, and allergic rhinitis). The infant nasal microbiome was associated with many environmental factors including prenatal smoke exposure and older siblings.Infants with viral presence had decreased alpha diversity and increased Moraxella sp.8 and Haemophilus sp.41. Additionally, the change in alpha diversity and individual operationaltaxanomic units (OTUs) between 3 and 12 months was associated with when infants had viral presence. Finally, infants with high asthma risk, wheeze and allergic rhinitis had multiple differentially abundant OTUs in infancy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".