The interleukin-10 knockout mouse: a model for studying bone metabolism during intestinal inflammation and the effects of flaxseed oil as a nutritional intervention
Bibliographic record
Abstract
There is a high prevalence of osteoporosis among patients with inflammatory bowel disease (IBD). Interleukin-10-/- (IL-10) knockout (KO) mice spontaneously develop IBD. The objective of study 1 was to determine if IL-10 KO mice develop abnormalities in bone metabolism during intestinal inflammation and subsequently, in study 2, to determine if a 10% flaxseed oil would attenuate these bone abnormalities. In study 1, IL-10 KO mice had greater intestinal inflammation and elevated serum proinflammatory cytokines compared to wild type (WT) mice. IL-10 KO mice had bone abnormalities including lower bone mineral content (BMC) and density (BMD). In study 2, the FO diet did not attenuate the intestinal inflammation or serum cytokines. FO diet did not improve bone metabolism. In conclusion, the IL-10 KO mouse is a good model for studying inflammation-associated bone abnormalities and potential therapeutic interventions but flaxseed oil at the level used is not an effective dietary strategy in IL-10 KO mice.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".