Focal Irradiation Regulates Distal Neural Stem and Progenitor Cell Behaviour
Bibliographic record
Abstract
Neural stem cells (NSCs) are located along the neuraxis of the adult central nervous system: in the dentate gyrus and subventricular zone (SVZ) of the forebrain as well as the periventricular zone of the spinal cord. Cranial irradiation (IR), a common cancer treatment, leads to fewer brain NSCs and impaired neurogenesis. Herein, we investigated how focal IR impacts distal, non-irradiated NSC niches, termed the “long-distance effect”. We demonstrated that focal cranial IR reduced the numbers of spinal cord derived NSCs at 2 days post-IR. Reciprocally, spinal cord IR led to fewer NSCs and depleted neuroblast pools in the forebrain. Since microglia activation is associated with impaired neurogenesis, we hypothesized that microglia ablation would rescue the IR-mediated effects on forebrain neurogenesis. However, microglia ablation paradigms did not reverse the neural stem and progenitor cell loss. Hence, focal IR alters NSC behaviour along the neuraxis, in the presence or absence of microglia.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".