Effects of Centromedian Thalamic Deep Brain Stimulation on Glutamate GABA in the Cntnap2-KO Mouse Model of Epilepsy
Bibliographic record
Abstract
Deep brain stimulation (DBS) of the centromedian nucleus of the thalamus (CM) is a promising treatment for a subset of individuals with drug-resistant epilepsy. However, the effects of CM-DBS on neurotransmitters involved in excitatory/inhibitory balance, such as glutamate and GABA, are unknown.Here, I studied the effects of CM-DBS on glutamate and GABA levels in healthy (C57BL/6J) and epilepsy (Cntnap2KO) mouse models. At baseline, Cntnap2KO mice had lower striatal Glu/GABA ratios in comparison to healthy mice. CM-DBS led to increases in striatal glutamate levels and hippocampal GABA levels. Additionally, I analyzed neurotransmitters from a network perspective. Inter-regional neurotransmitter correlations involving the striatum were weaker in Cntnap2KO mice compared to healthy mice, and CM-DBS reversed the direction of these correlations. These findings provide initial insights into mechanisms involving glutamate/GABA neurotransmission that potentially underlie the anti-seizure effects of CM-DBS.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".