Identifying Probiotics that Modulate Mitophagy in Models of Mitochondrial Dysfunction
Bibliographic record
Abstract
Disruption of mitophagy in neurons is linked to Parkinson’s disease (PD), which is a multifactorial neurodegenerative disorder that currently has no cure. The neuroprotective effect of probiotics has become an emerging field of study due to growing evidence of the link between the health of the GI tract and the CNS. In various animal models and clinical trials, probiotic supplementation led to the alleviation of PD-like symptoms, while the mechanism of function remains unknown. The aim of this thesis was to identify probiotics that can potentiate mitophagy under mitochondrial stress and determine the active component(s). Utilizing cellular assays and a Drosophila model of PD, I validated that the probiotics Saccharomyces boulardii CNCM-I-1079 and Lactococcus lactis R1058 can induce Parkin-dependent mitophagy under mitochondrial stress, and only probiotics with mitophagy modulating ability shown neuroprotective effects. I also demonstrated that the small molecule MI6C is an active component released by CNCM-I-1079 and R1058 that induces mitophagy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".