Endocannabinoid Metabolism in Posttraumatic Stress Disorder: Preliminary Results from a Neuroimaging Study with the Novel Fatty Acid Amide Hydrolase Probe [C-11] CURB
Bibliographic record
Abstract
Background: Preclinical studies suggest that levels of Fatty Acid Amide Hydrolase (FAAH)—the catabolic enzyme for the endocannabinoid anandamide—may be elevated in the amygdala in posttraumatic stress disorder (PTSD). However, the status of FAAH in vivo in posttraumatic stress disorder remains unknown. Methods: Healthy subjects (n=29) and individuals with PTSD (n=16) completed a positron emission tomography scan following injection of the FAAH probe [C-11]CURB. Results: We find no evidence for elevated [C-11]CURB binding in PTSD. Instead, we find marginally lower [C-11]CURB binding in whole brain (-9.38%, p=0.079) and significantly lower [C-11]CURB binding in the amygdala (-14.50%, p=0.020) in PTSD subjects. [C-11]CURB binding did not correlate with PTSD symptomatology. Conclusion: Our data provide preliminary evidence contrary to preclinical literature, suggesting that FAAH may be lower in people with PTSD. These findings have implications for treatment strategies targeting this enzyme (i.e. FAAH inhibitors) in PTSD.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".