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Record W7133097787

Analyzing high-dimensional microarray data using Variational-SOM

2005· dissertation· W7133097787 on OpenAlexfundno aff
Linghai Zhang

Bibliographic record

VenueTSpace · 2005
Typedissertation
Language
FieldBiochemistry, Genetics and Molecular Biology
TopicGene expression and cancer classification
Canadian institutionsnot available
FundersUniversity of Toronto
KeywordsCurse of dimensionalityMicroarray analysis techniquesMicroarray databasesArtificial neural networkDimensionality reductionClustering high-dimensional dataPattern recognition (psychology)Gene chip analysisCluster analysis
DOInot available

Abstract

fetched live from OpenAlex

This thesis focuses on analyzing high-dimensional microarray data using the proposed algorithm, Variational-SOM. The original Self-Organizing Map (SOM) algorithm is an unsupervised neural network method and can be used to reduce the dimensionality of microarray data. The main disadvantage of SOM is that the topology of the map must be fixed from the beginning. In order to solve the problem, the Variational-SOM, of which the map's topology is determined dynamically, is proposed. The DNA microarray technology makes it possible to monitor expression levels of thousands of genes simultaneously. However, these data are of little use unless we are able to analyze them. Experimental results show that the Variational-SOM can reduce the dimensionality of data according to the information that the data contains and help to extract biological significance from the data. The analysis using Variational-SOM can produce more well-separated clusters with respect to clinical information than using the original SOM.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.003
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.038
GPT teacher head0.356
Teacher spread0.318 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2005
Admission routes1
Has abstractyes

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