Loss of Bat3 on T Cells Impairs Response to Viral Infection via Altered T cell-NK Cell Crosstalk
Bibliographic record
Abstract
Factors regulating T cell and innate lymphoid cell (ILC) cross-talk ensure coordinated immune responses. Human leukocyte antigen-B-associated transcript 3 (Bat3) protects T cells from Tim-3-induced exhaustion and regulates human Natural Killer (NK) cells. Herein, we use Bat3flox/flox CD4-cre mice in the RIP-gp model to demonstrate that loss of Bat3 on T cells impairs CD8+ T cell-mediated tissue destruction and reduces CD4+ T cells proliferation, expression of activation markers, and TNF- and IFN- production. Furthermore, we show mice lacking T cell-expressed Bat3 have a CD49b+NK1.1+ ILC population that expresses high levels of Galectin-9 and IL-22, and expands following viral infection. Depletion of NK1.1+ cells or ILCs (Nfil3-/-) restores normal T cell activity in vivo, and T cell proliferation and activation marker expression is restored in Bat3flox/flox CD4-cre Nfil3-/- mice. Collectively, this thesis provides evidence that NK cell regulation of anti-viral T cell responses is influenced by T cell expression of Bat3.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".