The evaluation of in vitro activity of potentially antifungal compounds by microdilution broth method. VIII.
Bibliographic record
Abstract
Kvítková L.: Evaluation of in vitro activity of potentially antifungal compounds by microdilution broth method - VIII. Over 250 new synthetized compounds divided into 16 chemical groups were tested by microdilution broth method for the establisment of in vitro antifungal activity. This method is based on the standard M27-A (Clinical Laboratory Standard Institute). RPMI 1640 medium buffered to pH 7.0 with MOPS was used and standardized inoculum was prepared from fresh fungal isolates grown on Sabouraud agar. All compounds tested were dissolved and diluted in DMSO. The MICs were determinated visually after 24 or 48 hours of incubation at 35C. The compounds were tested against eight fungal strains. The structure-activity relationships were studied and compared with the calculated log P values. Hydrophobicity of compounds (log P) was computed using the program ACD/LogP (Advanced Chemistry Development Inc., Ontario, Canada). The most active compounds were the derivatives of (E)-1-pyrazine-2- ylethane-1-one-thiosemicarbazone; the majority of the compounds showed moderate or high efficacy against all fungal strains tested. There were several compounds of the groups tested with a considerable antifungal effect, as well. The most susceptible fungal strain was Trichophyton mentagrophytes, on the contrary,...
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".