Bibliographic record
Abstract
This dissertation thesis deals with the antimicrobial susceptibility testing of newly prepared compounds based on quaternary ammonium salts (KAS) and their reference standards commonly used in practice. The new compounds were prepared in cooperation with the Department of Toxicology and Military Pharmacy of the Faculty of Military Health Sciences of the University of Defence and the Biomedical Research Centre at the University Hospital Hradec Králové as a part of joint projects. The antimicrobial activity was established on gram-positive (G+) and gram-negative (G-) bacteria from type culture collections and clinical isolates, in planktonic and biofilm form. At first, the basic antimicrobial activity evaluation was performed by using the microdilution broth method. Additionally, the modified methodology was used to explore the influence of culture broth and initial bacterial density on evaluating the antimicrobial activity. Secondly, by using the quantitative suspension test, that better simulates normal practice conditions, has been successfully implemented at the department for the detailed antimicrobial activity evaluation. Thirdly, the biofilm model based on the Calgary Biofilm Device was successfully introduced and optimized for antibiofilm activity testing. Detailed antibiofilm activity was...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".