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Record W7135723472

Antimicrobial efficacy of quaternary ammonium salts

2024· dissertation· cs· W7135723472 on OpenAlex
Michaela Hympánová

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueDigital Repository (National Repository of Grey Literature) · 2024
Typedissertation
Languagecs
FieldEnvironmental Science
TopicEnvironmental Chemistry and Analysis
Canadian institutionsnot available
Fundersnot available
KeywordsAntimicrobialBroth microdilutionAmmoniumBiofilmBacteriaAntibacterial activity
DOInot available

Abstract

fetched live from OpenAlex

This dissertation thesis deals with the antimicrobial susceptibility testing of newly prepared compounds based on quaternary ammonium salts (KAS) and their reference standards commonly used in practice. The new compounds were prepared in cooperation with the Department of Toxicology and Military Pharmacy of the Faculty of Military Health Sciences of the University of Defence and the Biomedical Research Centre at the University Hospital Hradec Králové as a part of joint projects. The antimicrobial activity was established on gram-positive (G+) and gram-negative (G-) bacteria from type culture collections and clinical isolates, in planktonic and biofilm form. At first, the basic antimicrobial activity evaluation was performed by using the microdilution broth method. Additionally, the modified methodology was used to explore the influence of culture broth and initial bacterial density on evaluating the antimicrobial activity. Secondly, by using the quantitative suspension test, that better simulates normal practice conditions, has been successfully implemented at the department for the detailed antimicrobial activity evaluation. Thirdly, the biofilm model based on the Calgary Biofilm Device was successfully introduced and optimized for antibiofilm activity testing. Detailed antibiofilm activity was...

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.016
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.224
Teacher spread0.219 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it