Gray Matter Volume Changes in the Apathetic Elderly
Why this work is in the frame
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Bibliographic record
Abstract
This study is to test the hypothesis that apathy in healthy participants is closely related to the prefrontal-basal-ganglia circuit and associated structural changes.We selected 36 healthy aged participants with (n = 18) or without apathy (n = 18) from our database.Participants underwent structural MRI scanning, providing data for voxel-based morphometric analysis to explore gray matter changes associated with apathy.Compared to the non-apathy group, the apathy group showed reduced gray matter volume of the right putamen, whereas volumes of the bilateral inferior frontal gyri and left inferior occipital gyrus showed increase.When depression scores were included in a regression model as a covariate, apathetic participants showed decreased gray matter volume in the right precentral gyrus compared to the non-apathetic participants.These findings suggest that apathy is associated with the gray matter volume in the prefrontal-basal-ganglia network, and may have a neuroanatomical basis distinct from depression in healthy elderly.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it