Research on the mechanism by which a high-fiber diet regulates the gut microbiota-bile acid metabolism axis and improves glucose metabolism
Bibliographic record
Abstract
This study examined how a high-fiber diet affects the gut–bile-acid pathway and blood sugar control in mice with type 2 diabetes. Thirty-six male C57BL/6J mice were assigned to three groups: normal control, diabetic control, and high-fiber diet. After 12 weeks, bile acids, gene markers, and gut bacterial changes were tested. LC–MS/MS showed that total secondary bile acids increased by 62%, intestinal FXR expression dropped by 35%, and plasma FGF19 rose about two times compared with diabetic controls. Gut RNA data showed higher activity of bile-acid–related genes and more Faecalibacterium, which was strongly linked with dehydroxylation levels (r = 0.78, P < 0.01). These results show that a high-fiber diet changes bile-acid balance through gut bacteria and adjusts the FXR–FGF19 signal to support better glucose control. The findings suggest that adding dietary fiber may be a simple and safe way to improve metabolism in diabetes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".