Chemical Constituents and Anti-dengue Activity of the Metabolites from Helicia Petelotii Collected in Sapa, Vietnam
Why this work is in the frame
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Bibliographic record
Abstract
From the leaves, twigs, and fruits of Helicia petelotii collected from the Hoang Lien mountain range in Sapa, Vietnam, six compounds were isolated including β-sitosterol (1), daucosterol (2), 3-O-[β-D-(6'-nonadecanoate)glucopyranosyl]-β-sitosterol (3), β-arbutin (4), breynioside B (5), and glycerol monostearate (6). Among them, compounds 3 and 6 were isolated from the fruits, while compounds 1, 2, 4, and 5 were obtained from the leaves and twigs. Advanced spectroscopic methods such as NMR and HR-ESI-MS were applied to accomplish the structures identification of the above compounds. The anti-denge potential of compounds 1-6 were examined against two dengue virus serotypes, DENV-1 and DENV-2. Among them compounds 3 and 5 demonstrated inhibitory activity against DENV-2, with PNRT₅₀ values of 18.25 µM and 159.43 µM, respectively, while the remaining compounds were inactive against all the virus serotypes. This is the first report of phytochemicals and antiviral properties of Helicia petelotii against Dengue virus.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it