Chemical Constituents and Anti-dengue Activity of the Metabolites from Helicia Petelotii Collected in Sapa, Vietnam
Bibliographic record
Abstract
From the leaves, twigs, and fruits of Helicia petelotii collected from the Hoang Lien mountain range in Sapa, Vietnam, six compounds were isolated including β-sitosterol (1), daucosterol (2), 3-O-[β-D-(6'-nonadecanoate)glucopyranosyl]-β-sitosterol (3), β-arbutin (4), breynioside B (5), and glycerol monostearate (6). Among them, compounds 3 and 6 were isolated from the fruits, while compounds 1, 2, 4, and 5 were obtained from the leaves and twigs. Advanced spectroscopic methods such as NMR and HR-ESI-MS were applied to accomplish the structures identification of the above compounds. The anti-denge potential of compounds 1-6 were examined against two dengue virus serotypes, DENV-1 and DENV-2. Among them compounds 3 and 5 demonstrated inhibitory activity against DENV-2, with PNRT₅₀ values of 18.25 µM and 159.43 µM, respectively, while the remaining compounds were inactive against all the virus serotypes. This is the first report of phytochemicals and antiviral properties of Helicia petelotii against Dengue virus.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".