Vitamin D dose-response study to establish dietary requirements in infants: a pilot study
Bibliographic record
Abstract
The primary objective of this study was to identify a daily dosage of oral vitamin D for optimal vitamin D status and growth in infants. Breastfed infants (n=32) were randomized to 400, 800, 1200 or 1600 IU/day of vitamin D3 beginning at one month of age. Blood samples collected at baseline, 4 and 8 weeks thereafter were analyzed for serum 25 (OH) D, parathyroid hormone, alkaline phosphatase, and total and ionized calcium. Growth was assessed by anthropometry and bone mineral content and density by dual-energy x-ray absorptiometry. Infants showed normal growth throughout the study. Significant increases in 25(OH) D were observed in the 800 IU, 1200 IU and 1600 IU, but not 400 IU, treatment groups. Only 50% of infants receiving 400 IU/day had 25(OH) D concentrations at the optimal 75 nmol/L cutoff. Thus 400 IU/day of vitamin D3 may be inadequate to achieve optimal vitamin D status for 97% of Canadian infants.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".