Oxygen dependence of mitochondrial respiration in high and low altitude birds
Bibliographic record
Abstract
We examined the oxygen dependence of mitochondrial respiration in the high altitude bar‐headed goose and several low altitude waterfowl species (greylag goose, barnacle goose, and mallard duck). Mitochondria were isolated from the flight muscle and their respiration was measured by high‐resolution respirometry at avian body temperature (41°C), with malate/pyruvate or malate/pyruvate/succinate fuel combinations. Mitochondria were well coupled with high phosphorylation efficiencies in all birds. Respiratory capacities, cytochrome oxidase excess capacity, and uncoupled respiration rates were all similar between species. Oxygen kinetics depended on respiration state, as half‐maximal mitochondrial respiration occurred at O 2 tensions (P 50 ) of 0.1‐0.2 Torr in State 4 (no ADP) and 0.8‐0.9 Torr in State 3 (maximal ADP). These data suggest that intramyocellular O 2 tension could regulate mitochondrial respiration during flight, particularly at high altitude where O 2 supply is reduced. (Supported by NSERC of Canada)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".