The effect of a human pancreatic α‐amylase inhibitor, montbretin A, on the chronic treatment of type 2 diabetes
Bibliographic record
Abstract
Montbretin A, a purified glycosylated acyl flavonol, was isolated from extracts of the plant Crocosmia crocosmiflora. Montbretin A has been shown to be a specific inhibitor of human pancreatic α‐amylase (HPA). The objective of this study was to determine if chronic administration of montbretin A and acarbose, an inhibitor of α‐glucosidases and HPA, could prevent and/or delay the onset of diabetes in the Zucker Diabetic Fatty (ZDF) rat. Montbretin A (7.5 mg/kg/day) and acarbose (10 mg/kg/day) were administered to ZDF and lean littermate controls for 60 days. Plasma was analyzed for glucose, insulin, triglyceride, cholesterol, alanine transaminase (ALT) and 8‐isoprostane. Both montbretin A and acarbose attenuated the increase in plasma glucose levels in the ZDF rat. There was no effect of montbretin A or acarbose on lipid parameters. All ZDF animals had elevated ALT levels; however, ALT levels were significantly higher in the acarbose treated group, which may indicate an exacerbation of liver damage. This study indicates that montbretin A is as effective as acarbose in lowering plasma glucose levels; further studies are ongoing to assess the side effect profile of montbretin A. Project was funded by the Canadian Institutes of Health Research and supported by the Centre of Drug Research and Development.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".