Adenosine and NO blockade decreases skeletal muscle interstitial pH during hypoxia
Bibliographic record
Abstract
The present study examined the effects that blocking local adenosine and nitric oxide production has on skeletal muscle interstitial pH and H + during hypoxia. Eight anesthetized rats had two microdialysis fibers inserted into the gastrocnemius muscle of each leg and perfused with Ringers (control) or 500 μM AOPCP (5′ectonucleotidase inhibitor) plus 10 mM L‐NAME (NOS inhibitor). Following baseline collections (20 min with saline, Baseline 1), all the probes were perfused with the both blockers for (20 min, Baseline 2) followed by 20 min of hypoxia (inhalation of 10.5% O 2 ) and recovery. The perfusion of the blockers resulted in a decrease (P<0.05) in skeletal muscle interstitial pH and a reciprocal increase (P<0.05) in interstitial H + during normoxia (Baseline 2) and these changes were further exaggerated during hypoxia as well as recovery (Figures)1. These data clearly demonstrate that blocking local vasodilators most likely resulted in a decrease in local tissue blood flow and an accumulation of H + , which is further elevated under anaerobic conditions such as hypoxia.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".