Bibliographic record
Abstract
Snail family proteins play a key role in epithelial-mesenchymal transition. Up-regulated expression of Snail has been detected during embryogenesis and tumor progression. Although hypoxia has been implicated in up-regulating Snail expression, no hypoxia-responsive elements in the Snail promoter have been identified. To investigate the underlying mechanism responsible for hypoxia-induced Snail expression, we searched in silico the human and mouse Snail promoter for potential HRE (Hypoxia-Inducible Elements) sites. Two potential HREs were identified of which one was located in the proximal promoter of both species. In subsequent experiments with endothelial cells, we isolated and characterized the proximal Snail hypoxia-responsive element using gel shift and reporter gene assays. Furthermore, we demonstrated that hypoxia-inducible transcription factors, HIF-1α and HIF-2α, bound to this HRE, thereby activating Snail transcription. Chromatin immuno-precipitation assay confirmed the interaction between HIF proteins and the Snail HRE in endothelial cells. Our findings identify Snail as a new HIF target gene and provide new insights into the regulation of Snail.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".