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Can Cod Protein Improve Skeletal Muscle Repair Following Injury?

2011· article· en· W771195785 on OpenAlexafffundabout
Junio Dort, Nadine Leblanc, Joannie Bolduc, Julie Maltais‐Giguère, Claude H. Côt́e, Hélène Jacques

Bibliographic record

VenueThe FASEB Journal · 2011
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMuscle metabolism and nutrition
Canadian institutionsUniversité Laval
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsCaseinSkeletal muscleMuscle proteinInternal medicineSalineEndocrinologyDietary proteinSoleus muscleChemistryMedicineBiochemistry

Abstract

fetched live from OpenAlex

It has been recently shown that cod protein can modulate the production of pro‐inflammatory cytokines. We therefore postulated that it may regulate muscle regeneration and promote muscle mass recovery. The aim of this study was to determine the effects of dietary cod protein on skeletal muscle repair after injury compared with casein. Sixty four male Wistar rats were assigned to isoenergetic diets composed of either dietary cod protein or casein. After 21 d of ad libitum feeding, one tibialis anterior muscle (TA) was injured by bupivacaine injection (100μl) at the half proximal region while the contra‐lateral TA was injected with saline and served as sham. TA muscles collected at time 0 served as control. At day 14 post‐injury, values for muscle weight in both contra‐lateral (0.017) and injured groups (0.014) were higher in rats fed the cod protein diet, indicating better muscle mass recovery than in those fed the casein diet. Conversely, the cod protein diet led to lower pro‐inflammatory ED1 + macrophage density in both injured (P=0.008) and contra‐lateral sham (P=0.029) at day 24 post‐injury, suggesting that cod protein modulates the time course of inflammatory cell trafficking. Globally these data suggest that cod protein favors muscle growth and influences the inflammatory response, which potentially impact on recovery following injury. Supported by The Natural Sciences and Engineering Research Council of Canada.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.227
Teacher spread0.215 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2011
Admission routes3
Has abstractyes

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