Biological activity of avocado‐derived mannoheptulose in dogs
Bibliographic record
Abstract
Mannoheptulose (MH) is a 7‐carbon sugar found in avocados and other natural sources. It is proposed as a calorie restriction (CR) mimetic that delivers anti‐aging and health‐promoting benefits of CR without reducing food intake. Two studies were conducted to evaluate effects of MH on fasting insulin when fed as an avocado extract (AvX) to Labrador Retrievers (LR) and Fox Terriers (FT). Decreased fasting insulin is commonly associated with CR and longevity. In Study 1, 36 dogs, balanced by breed (18 LR; 18 FT) and age (18 young, 2.6 yr; 18 old, 11.8 yr), received control or test treatments during sequential 2‐week periods. Test dogs were fed one AvX‐containing gelatin capsule daily to deliver 1, 2, 10 or 20 mg MH/kg BW in a step‐up fashion. Control dogs were fed one placebo capsule daily. Fasting blood samples were collected weekly. Fasting insulin was lower (P<0.05) in dogs fed 2, 10 and 20 mg/kg. In Study 2, LR (15) and FT (15) were fed an AvX‐containing diet providing 0, 2 or 5 mg MH/kg BW. A glycemic meal challenge was induced on days 0 and 30 by feeding dogs one‐half their daily meal allotment after an overnight fast. Blood samples for insulin and glucose were collected at 0, 30, 60, 120 and 240 min post‐feeding. MH (2 mg/kg) reduced (P<0.05) insulin levels (mean, peak, area under curve) in old LR on day 30. Glucose was not affected by MH. Lower plasma insulin implies mannoheptulose is biologically active in dogs when fed as an avocado extract.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".