Mesenteric artery vasomotor function in normotensive and hypertensive rats
Bibliographic record
Abstract
Endothelium‐derived hyperpolarizing factor (EDHF) contributes to vascular dilation but its chemical identity is unknown. Decreased EDHF‐mediated dilation, assessed with inhibited prostaglandin and nitric oxide production, may lead to impaired vasomotion in spontaneously hypertensive rats (SHR). Mesenteric arteries were excised from SHR and normotensive (WKY) rats and myography was performed. Vessels were incubated with 3μM of the β‐blocker propranolol, pre‐contracted with norepinephrine, and cumulative dose‐response curves for acetylcholine (Ach) were conducted. The Ach response was impaired in SHR compared to WKY (63±4% vs 95±9%, p=0.0021). 0.3mM of the nitric oxide inhibitor N ω ‐nitro‐L‐arginine (L‐NAME) reduced the Ach response in SHR (20±4%, p<0.0001) whereas 5μM of the cyclooxygenase inhibitor indomethacin (INDO) improved the Ach response in SHR (83±4%, p=0.0019). Incubation with both inhibitors improved the Ach response over L‐NAME alone in SHR (47±6% vs 20±4%, p=0.0003). The Ach response in WKY was not altered by INDO or L‐NAME. Incubation with both inhibitors reduced the Ach response in SHR (47±6%, p=0.0268) but did not alter WKY. Reduced EDHF may contribute to SHR vascular dysfunction and future studies will aim to identify the specific EDHF contributing to altered vasomotion. Funding: Natural Sciences and Engineering Research Council of Canada and the Heart and Stroke Foundation of Ontario
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".