Elf3 plays a role in regulating dendritic cell maturation and function (100.42)
Bibliographic record
Abstract
Abstract Elf3 belongs to the family of epithelium-specific Ets transcription factors and can be upregulated in non-epithelial cells upon cytokine stimulation. Among Ets family transcription factors, Elf3 is most highly induced during inflammation, yet its function is not well understood. Here we demonstrate an important role of Elf3 in regulating dendritic cell (DC) function. Intraperitoneal injection of ovalbumin (OVA)-Alum to Elf3-/- mice resulted in increased migration of DCs to the peritoneal space along with hypermaturation followed by increase in subsequent migration of DCs to the draining lymph nodes. In vitro cultured Elf3-/- DCs underwent spontaneous maturation in absence of any inflammatory stimuli and upon exposure to inflammatory stimuli underwent hypermaturation compared to Elf3+/+ DCs, indicating a role of Elf3 in regulation DC maturation. Elf3-/- mice had normal T cell development but mounted an exaggerated Th2 response upon OVA exposure. Naïve T cells cultured with Elf3-/- DCs showed impairment in Th1 and Th17 differentiation with an increased propensity for Th2 differentiation. This was mediated by an impairment of IL-6 and IL-12 production by Elf3-/- DCs. The impairment of IL-6 and IL-12 production was due to impairment of IL-6 and IL-12p40 gene induction in Elf3-/- DCs in response to inflammatory stimuli. Impairment of Th1 differentiation promoted Th2 differentiation. Taken together, our findings identify a role of Elf3 in regulating DC maturation and function.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".