Abstract 8543: Ectopic Fat Mobilization Following a Bariatric Surgery-Induced Weight Loss; Association with Insulin Resistance
Bibliographic record
Abstract
Severe obesity is associated with increased cardiovascular morbidity and mortality and is increasing in prevalence. The purpose of the study was to measure the impact of weight loss and changes in insulin resistance following biliopancreatic diversion with duodenal switch (BPD-DS) procedure on adiposity and skeletal muscle. Anthropometric measures, mid-thigh computed tomography (CT) and fasting plasma glucose and insulin were measured at baseline, at 6 and 12 months in severely obese subjects who underwent BPD-DS (n=43) and in a severely obese control group (n=24). At baseline, the two groups were similar for age, sex, weight (128.3±23.3 vs. 117.6±19.1 kg; p=0.059, BPD-DS vs. control respectively) and mid-thigh CT composition but not for body mass index (BMI) (47.6±5.9 vs. 43.5±4.8 kg/m2; p=0.004). At 6 months, in the BPD-DS group, there were a significant decrement in weight (-26.7±7.4%), BMI (-26.7±5.6%), as well as in mid-thigh CT composition: total adipose tissue (-34.7±10.5%), deep adipose tissue (-36.1±15.4%), subcutaneous adipose tissue (-34.7±10.5%), total skeletal muscle (-19.2±8.8%), fat infiltrated muscle (-54.4±29.4%) and non-fat infiltrated muscle (-17.7±11.4%); all p<0.001. Between month 6 and 12, in the BDP-DS group, weight, BMI, total, deep and subcutaneous adipose tissue decrease significantly but to a lesser degree compared to the first 6 month; all p≤0.001. There was no change regarding total skeletal muscle, but a significant increment in non-fat infiltrated muscle (5.3±7.8%) and decrement in fat infiltrated muscle (-11.8±10.8%); all p≤0.001. A decreased in insulin resistance at 6 and 12 months was associated with a reduction of thigh deep adipose tissue (r=0.469, r=0.692, 6 and 12 months respectively) and fat infiltrated muscle (r=0.469, r=0.526); all p≤0.001. There were no changes, in all these parameters in the control group. BPD-DS surgery-induced weight loss had major impact on muscle and fat mass. Mobilization of thigh ectopic fat; thigh deep adipose tissue and fat-infiltrated muscle, may be one mechanism that improves insulin resistance. Muscle regain at 12 months suggests that BPD-DS exerts a physiologic effect beyond that of nutrient restriction on the regulation of energy metabolism.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".