SaO012LONGITUDINAL EFFECT OF BIOCOMPATIBLE SOLUTIONS ON PERITONEAL SOLUTE TRANSPORT: RESULTS FROM THE GLOBAL FLUID STUDY
Bibliographic record
Abstract
Introduction and Aims: Long term PD is associated with adverse changes in the peritoneal membrane, such as an increased solute transport demonstrating increased vascularity. Biocompatible solutions (BCS) were developed to mitigate this damage, so we examined their effect on solute transport. Methods: We analysed the Global Fluid Study, a multinational cohort study. Included adults had 3 or more PET measurements more than 2 months from the start of PD who remained on a single solution type. Follow up was up to 7.5 years (median of 2.3) in BCS and 12.8 (median 3.2) in standard solutions (SS). A random intercept/slopes linear mixed model assessed the effect of BCS on dialysate to plasma creatinine ratio (D/P Cr) over time for each solution, adjusted for centre, glucose exposure, baseline dialysate IL-6 levels, Icodextrin, residual renal function (RRF) and peritonitis. Results: Of 366 patients, 71 received BCS (58 Baxter Physioneal(BP), 8 Fresenius Balance(FB) and 5 Gambrosol Trio(GT)). After 2 months of PD the BCS group had a mean predicted D/P Cr of 0.67 compared to 0.72 for the SS group (p=0.02). The trends over time also differed (p=0.002), with the BCS group D/P Cr increasing initially, peaking at 0.749 by 2.1 years, with no further increase. SS had a slow continuous increase in D/P Cr. A sensitivity analysis split patients into BP and FB/GT with a difference between groups of borderline significance (p=0.06). Peritonitis correlated with an increase in D/P Cr of 0.019 per episode for SS (p=<0.0001), but there was no effect in BCS (p=<0.0001). Baseline dialysate IL-6, RRF, glucose exposure and Icodextrin also predicted D/P Cr. Age, APD usage, comorbidity, gender and plasma IL-6 were not significantly associated with D/P Cr.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".