CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
2006· article· en· Nature Genetics· Medicine
affno abstract
1,985
citations
Works
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330 workspage 1 of 14
Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas
2018· article· en· Cancer Cell· Medicine
affno abstract
710
citations
The Clinical Phenotype of Lynch Syndrome Due to Germ-Line PMS2 Mutations
2008· article· en· Gastroenterology· Medicine
affno abstract
548
citations
Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer
2016· article· en· Cancer Epidemiology Biomarkers & Prevention· Medicine
affabout
527
citations
Lymphocytic Reaction to Colorectal Cancer Is Associated with Longer Survival, Independent of Lymph Node Count, Microsatellite Instability, and CpG Island Methylator Phenotype
2009· article· en· Clinical Cancer Research· Medicine
fundno aff
419
citations
Prediction of Germline Mutations and Cancer Risk in the Lynch Syndrome
2006· article· en· JAMA· Medicine
affabout
386
citations
Comprehensive Biostatistical Analysis of CpG Island Methylator Phenotype in Colorectal Cancer Using a Large Population-Based Sample
2008· article· en· PLoS ONE· Medicine
fundno aff
310
citations
Prevalence of Germline Mutations in Cancer Predisposition Genes in Patients With Pancreatic Cancer
2014· letter· en· Gastroenterology· Biochemistry, Genetics and Molecular Biology
affno abstract
298
citations
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing
2015· article· en· Genetics in Medicine· Biochemistry, Genetics and Molecular Biology
fundno aff
288
citations
Metachronous colorectal cancer risk for mismatch repair gene mutation carriers: the advantage of more extensive colon surgery
2010· article· en· Gut· Medicine
aff
283
citations
Risks of Primary Extracolonic Cancers Following Colorectal Cancer in Lynch Syndrome
2012· article· en· JNCI Journal of the National Cancer Institute· Medicine
aff
275
citations
LINE‐1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
2008· article· en· International Journal of Cancer· Medicine
fundno aff
263
citations
Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches
2013· article· en· PLoS Genetics· Neuroscience
aff
258
citations
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1–mutant mice
2004· article· en· Nature Immunology· Biochemistry, Genetics and Molecular Biology
affno abstract
245
citations
234
citations
Demographic and pathological characteristics of serrated polyps of colorectum
2005· article· en· Histopathology· Medicine
afffund
231
citations
Molecular Characterization of MSI-H Colorectal Cancer by MLHI Promoter Methylation, Immunohistochemistry, and Mismatch Repair Germline Mutation Screening
2008· article· en· Cancer Epidemiology Biomarkers & Prevention· Medicine
aff
228
citations
Clinical Management and Tumor Surveillance Recommendations of Inherited Mismatch Repair Deficiency in Childhood
2017· review· en· Clinical Cancer Research· Medicine
aff
221
citations
Detection of DNA mismatch repair (MMR) deficiencies by immunohistochemistry can effectively diagnose the microsatellite instability (MSI) phenotype in endometrial carcinomas
2015· article· en· Gynecologic Oncology· Medicine
afffundno abstract
219
citations
Disease-associated repeat instability and mismatch repair
2015· review· en· DNA repair· Neuroscience
affno abstract
209
citations
MLH1 Germline Epimutations as a Factor in Hereditary Nonpolyposis Colorectal Cancer
2005· article· en· Gastroenterology· Medicine
affno abstract
198
citations
The PREMM1,2,6 Model Predicts Risk of MLH1, MSH2, and MSH6 Germline Mutations Based on Cancer History
2010· article· en· Gastroenterology· Medicine
affno abstract
185
citations
Heterogenous loss of mismatch repair (MMR) protein expression: a challenge for immunohistochemical interpretation and microsatellite instability (MSI) evaluation
2018· article· en· The Journal of Pathology Clinical Research· Medicine
aff
167
citations
Recurrence and variability of germline EPCAM deletions in Lynch syndrome
2011· article· en· Human Mutation· Medicine
aff
152
citations
Extensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis
2006· article· en· Gut· Medicine
afffund
147
citations