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Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

2018· article· en· 710 citations· W2795622837 on OpenAlex· 10.1016/j.ccell.2018.03.010

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Non-randomized trialObservationalCase reportBench or experimental
Classifier consensus
ObservationalBench or experimental
Teacher imitation scores

Codex

Bench or experimental0.717
Observational0.381
Other design0.035
Meta-analysis0.004
Case report0.000
Qualitative0.000
Simulation or modelling0.000
Bibliometrics0.000
Non-randomized trial0.000
Research integrity0.000
Meta-epidemiology (broad)0.000
Metaresearch0.000
Meta-epidemiology (narrow)0.000
Open science0.000
Systematic review0.000
Science and technology studies0.000
Scholarly communication0.000
Theoretical or conceptual0.000
Not applicable0.000
Randomized trial0.000

Gemma

Observational0.606
Bench or experimental0.230
Case report0.022
Meta-analysis0.004
Simulation or modelling0.001
Non-randomized trial0.001
Qualitative0.000
Research integrity0.000
Bibliometrics0.000
Meta-epidemiology (broad)0.000
Not applicable0.000
Metaresearch0.000
Meta-epidemiology (narrow)0.000
Science and technology studies0.000
Open science0.000
Systematic review0.000
Scholarly communication0.000
Randomized trial0.000
Theoretical or conceptual0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.033
GPT teacher head0.328
Teacher spread
0.295 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/deletions, representing microsatellite instability cases with epigenetic silencing of MLH1 in the context of CpG island methylator phenotype, plus tumors with elevated single-nucleotide variants associated…

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