Endosymbiotic Actinidic Archaea and Viroids Regulate Cellular Organelle Function, Cell Growth, Cell Differentiation and Cell Death
Notice bibliographique
Résumé
Background: A hypothesis regarding the role of endosymbiotic actinidic archaea and viroids in the regulation of cell function, cell differentiation, cell proliferation and cell death is discussed. Endomyocardial fibrosis (EMF) along with the root wilt disease of coconut is endemic to Kerala with its radioactive actinide beach sands. Actinides like rutile producing intracellular magnesium deficiency due to rutile-magnesium exchange sites in the cell membrane has been implicated in the etiology of EMF. Organisms like phytoplasmas and viroids have also been demonstrated to play a role in the etiology of these diseases. Actinidic archaea and viroids have been related to the pathogenesis of malignancies and degenerations. The actinidic archaea have a mevalonate pathway and cholesterol catabolism. An actinide dependent shadow biosphere of archaea and viroids regulating the cell cycle is described in the above mentioned disease states. Methods: The following groups were included in the study:- Group A: Non-hodgkin’s B cell lymphoma, multiple myeloma and cns glioma- glioblastoma multiforme. Group B :- Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Motor neuron disease. There were 10 patients in each group and each patient had an age and sex matched healthy control selected randomly from the general population. Cholesterol substrate was added to the plasma of the patients and the generation of cytochrome F420, free RNA, free DNA, polycyclic aromatic hydrocarbon, hydrogen peroxide, pyruvate, ammonia, glutamate, cytochrome C, hexokinase, ATP synthase, HMG CoA reductase, digoxin and bile acids were studied. The changes with the addition of antibiotics and rutile to the patient’s plasma were also studied. Results: The parameters mentioned above were increased the patient’s plasma with addition of cholesterol substrate. The addition of antibiotics to the patient’s plasma caused a decrease in all the parameters while addition of rutile increased their levels. Conc lus ion: An a c t inide dependent shadow biosphere of archaea and viroids is described in nonhodgkin’s B cell lymphoma, multiple myeloma and CNS glioma- glioblastoma multiforme producing the Warburg phenotype contributing to their pathogenesis. Actinidic archaea and viroids can also contribute to the cell death in Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Motor neuron disease. The role of actinidic archaea and viroids as well as endogenous digoxin in regulation of cell function, cell differentiation, cell proliferation and cell death is discussed. The endosymbiotic actinidic archaea and viroids can regulate the cell cycle and cellular organelle function. Key words : Archaea; Viroids; Cholesterol; Actinide; Non-Hodgkin’s Lymphoma; Multiple Myeloma; CNS Glioma; Alzheimer’s Disease; Parkinson’s Disease; Huntington’s Disease; Motor Neuron Disease; Cell Cycle; Organelle
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,002 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».