Endosymbiotic Actinidic Archaea and Viroids Regulate Cellular Organelle Function, Cell Growth, Cell Differentiation and Cell Death
Bibliographic record
Abstract
Background: A hypothesis regarding the role of endosymbiotic actinidic archaea and viroids in the regulation of cell function, cell differentiation, cell proliferation and cell death is discussed. Endomyocardial fibrosis (EMF) along with the root wilt disease of coconut is endemic to Kerala with its radioactive actinide beach sands. Actinides like rutile producing intracellular magnesium deficiency due to rutile-magnesium exchange sites in the cell membrane has been implicated in the etiology of EMF. Organisms like phytoplasmas and viroids have also been demonstrated to play a role in the etiology of these diseases. Actinidic archaea and viroids have been related to the pathogenesis of malignancies and degenerations. The actinidic archaea have a mevalonate pathway and cholesterol catabolism. An actinide dependent shadow biosphere of archaea and viroids regulating the cell cycle is described in the above mentioned disease states. Methods: The following groups were included in the study:- Group A: Non-hodgkin’s B cell lymphoma, multiple myeloma and cns glioma- glioblastoma multiforme. Group B :- Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Motor neuron disease. There were 10 patients in each group and each patient had an age and sex matched healthy control selected randomly from the general population. Cholesterol substrate was added to the plasma of the patients and the generation of cytochrome F420, free RNA, free DNA, polycyclic aromatic hydrocarbon, hydrogen peroxide, pyruvate, ammonia, glutamate, cytochrome C, hexokinase, ATP synthase, HMG CoA reductase, digoxin and bile acids were studied. The changes with the addition of antibiotics and rutile to the patient’s plasma were also studied. Results: The parameters mentioned above were increased the patient’s plasma with addition of cholesterol substrate. The addition of antibiotics to the patient’s plasma caused a decrease in all the parameters while addition of rutile increased their levels. Conc lus ion: An a c t inide dependent shadow biosphere of archaea and viroids is described in nonhodgkin’s B cell lymphoma, multiple myeloma and CNS glioma- glioblastoma multiforme producing the Warburg phenotype contributing to their pathogenesis. Actinidic archaea and viroids can also contribute to the cell death in Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Motor neuron disease. The role of actinidic archaea and viroids as well as endogenous digoxin in regulation of cell function, cell differentiation, cell proliferation and cell death is discussed. The endosymbiotic actinidic archaea and viroids can regulate the cell cycle and cellular organelle function. Key words : Archaea; Viroids; Cholesterol; Actinide; Non-Hodgkin’s Lymphoma; Multiple Myeloma; CNS Glioma; Alzheimer’s Disease; Parkinson’s Disease; Huntington’s Disease; Motor Neuron Disease; Cell Cycle; Organelle
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".