Diminished nitric oxide‐dependent sweating in older males during intermittent exercise in the heat
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Notice bibliographique
Résumé
New Findings What is the central question of this study? Sweating during exercise in the heat is, in part, mediated through nitric oxide‐dependent mechanisms. It is unclear whether ageing reduces nitric oxide‐dependent sweating during exercise in the heat. What is the main finding and its importance? Nitric oxide‐dependent sweating during short bouts of exercise in the heat was observed in young men, but not in older adults. These findings show that age‐related impairment in sweating may be associated with age‐related reductions in nitric oxide‐mediated sweating. Nitric oxide (NO) is a signalling molecule that contributes to the control of many physiological pathways, including the heat‐loss response of skin vasodilatation. Recently, NO has been implicated in the control of sweating during exercise in young adults. We tested the hypothesis that ageing reduces NO‐dependent sweating during exercise in the heat. Ten young (23 ± 3 years old) and 10 older men (64 ± 5 years old), matched for body surface area, performed three successive 15 min bouts of exercise (Ex1, Ex2 and Ex3) at the same rate of metabolic heat production (300 W m −2 ) in the heat (35°C, 20% relative humidity). Exercise periods were interspersed with 15 min recovery periods. Local sweat rate (ventilated capsule) was measured on two forearm skin sites, which were continuously perfused via intradermal microdialysis with 0.9% saline as control (CON) or 10 m m N G ‐nitro‐ l ‐arginine methyl ester ( l ‐NAME), a non‐selective NO synthase inhibitor. Local sweat rate at the end of Ex1 was lower in the CON conditions in the older versus young men (0.69 ± 0.19 versus 0.90 ± 0.17 mg min −1 cm −2 , P = 0.018). In the young men, local sweat rate was reduced in the l ‐NAME‐treated conditions compared with the CON conditions at the end of Ex1 (0.67 ± 0.14 versus 0.90 ± 0.17 mg min −1 cm −2 , P = 0.004), Ex2 (0.78 ± 0.20 versus 1.03 ± 0.20 mg min −1 cm −2 , P = 0.013) and Ex3 (0.78 ± 0.20 versus 1.03 ± 0.21 mg min −1 cm −2 , P = 0.014). In the older men, there was no main effect of treatment conditions on local sweat rate ( P = 0.537) such that local sweat rates in the l ‐NAME‐treated and CON conditions were similar (Ex1, 0.65 ± 0.20 versus 0.69 ± 0.19 mg min −1 cm −2 ; Ex2, 0.80 ± 0.27 versus 0.91 ± 0.29 mg min −1 cm −2 ; and Ex3, 0.84 ± 0.31 versus 0.94 ± 0.38 mg min −1 cm −2 ). We conclude that ageing attenuates the influence of NO in the control of local forearm sweating observed in young adults during short 15 min bouts of exercise in the heat. This mechanism may, in part, explain the age‐related impairments in sweating.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle