223 DEVELOPMENTAL PATTERN OF SMALL (1–3 mm) ANTRALFOLLICLES IN THE BOVINE OVARY
Notice bibliographique
Résumé
Knowledge about the developmental pattern of small follicles (<4 mm) will be crucial to understanding the endogenous control of folliculogenesis and to developing methods to control it for clinical purposes. This study was designed to characterize the developmental pattern of 1–3 mm follicles and to determine, retrospectively, the stage at which the future dominant follicle first attains a size advantage among follicles in the cohort. In Experiment 1, the ovaries of Hereford-cross heifers (n = 18) were examined daily by high resolution transrectal ultrasonography for one natural interovulatory interval to evaluate changes in the number of 1–3-mm follicles in relation to the wave pattern of follicles =4 mm. Interovulatory interval was divided into 2- and 3-wave based on number of waves exhibited by heifers. In Experiment 2, the ovaries of Hereford-cross cows (n = 9) were examined every 6 h from Day 5 to Day 13 (Day 0 = ovulation) to monitor precisely the diameter changes of individual follicles =1 mm during emergence of the second follicular wave. Data were analyzed by Proc. Mixed procedure for repeated measures (Littell RC et al., 2000 Stat in med 19, 1793–1819) in the Statistical Analysis System software package (SAS version 8.2 for MS Windows;; 2002 SAS Institute Inc. Cary, NC, USA). Results of Experiment 1 revealed a day effect (P < 0.05) on the number of small (1–3 mm) follicles, with a peak (P < 0.05) 1 or 2 days before wave emergence (defined as the day the dominant follicle was first detected at 4 mm), followed 3 to 4 days later by a peak (P < 0.05) in the number of large follicles (=4 mm). There was an inverse relationship between the number of small and large follicles during Wave 1 (r = -0.66; P = 0.05) and Wave 2 (r = -0.62; P = 0.04) in 2-wave interovulatory intervals. Similarly, an inverse relation was detected between the number of small and large follicles for Wave 1 (r = -0.79; P = 0.01) and Wave 3 (r = -0.90; P < 0.01) but not for Wave 2 (r = -0.57; P = 0.14) in 3-wave interovulatory intervals. The number of 1–3-mm follicles detected in anovulatory waves did not differ (P = 0.53) between 2- versus 3-wave interovulatory intervals;; however, a difference (P < 0.05) was observed between anovulatory and ovulatory waves in 3-wave interovulatory intervals but not (P = 0.63) in 2-wave interovulatory intervals. Experiment 2 permitted the identification of the future dominant follicle at a diameter of 1 mm and its emergence at 6–12 h earlier than the largest subordinate follicle (P < 0.01). Emergence of the future dominant (r = 0.71; P = 0.05) and 1st subordinate (r = 0.78; P = 0.02) follicles was temporally associated with a wave-eliciting rise in circulating concentrations of FSH. Growth rate of the dominant and the 1st subordinate follicle differed (P < 0.01) from 2nd subordinate follicle at 84 h after their detection at 1 mm. It was concluded that small antral follicles (1–3 mm) develop in a wave-like manner, and apparent selection of the dominant follicle was manifest much earlier than previously documented.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».