Evaluation of exercise tolerance in women receiving surgery and chemotherapy as treatment for stage II breast cancer
Notice bibliographique
Résumé
Worldwide, breast cancer is the second-most-common cause of cancer deaths in women (Harvey and Beattie, 1996). It is estimated that by the year 2000, one million women a year will receive a diagnosis of breast cancer, while in Canada alone, the disease develops in 18,400 women every year (National Cancer Institute of Canada, 1997). The development and improvement of new treatment modalities for breast cancer have resulted in increasing cure rates and longer disease-free survival making the outcome of cancer therapy increasingly important. Damaging effects of cancer therapies can occur in the heart and lungs and therefore are thought to impede the patient's functional capacity and ability to exercise. The purpose of this study was to characterize the early changes in functional capacity that occur in women diagnosed with stage II breast cancer, whose treatment involves a schedule of mastectomy and adjuvant chemotherapy. Nine female patients performed the treatment protocol at three different sessions: 1) after diagnosis of breast cancer but before surgery, 2) following surgery but before beginning chemotherapy, and 3) following chemotherapy. Testing sessions involved two protocols and the subjects served as their own controls throughout the three tests. Firstly, resting pulmonary function was assessed using the Spirometry software package on the Medical Graphics CPX-D Metabolic Cart. Forced Vital Capacity (FVC), forced expiratory volume in one second (FEV1), the ratio of the two (FEV1/FVC), and maximal voluntary ventilation (MVV) were measured. The second protocol was a V0₂max test on an electronically-braked cycle ergometer (Lode BV Excalibur V2.0) using a Medical Graphics CPX-D Exercise Testing System. Measurements included maximal heart rate (HRmax), minute ventilation (VE), maximal oxygen consumption (V02max), and peak power output (PPO). While cycling, percent arterial oxygen saturation (%Sa02) was monitored with a pulse oximeter (Ohmeda Box 3740). Anthropometric measures including height, weight and sum of skinfolds (SOS) were recorded before each test. Data was analyzed using a one-way repeated measures A N O V A design on SPSS and subsequent Tukey HSD post-hoc analyses were performed by hand. A probability value of < 0.05 was considered to provide significance. V 0 2 m a x values, measured both in L/min and ml/kg/min decreased significantly from baseline to the end of chemotherapy (1.70 ± 0.31 to 1.47 ± 0.31 L/min; and 28.3 ± 5.54 to 24.52 ± 6 . 1 3 ml/kg/min, respectively). FEV1/FVC and M V V did not change significantly throughout the treatment. PPO, HRm a x , Sa02 , and V E also remained unchanged after chemotherapy treatment. Although respiratory function was not affected, the data suggests that breast cancer patients treated with chemotherapy experience a decrease in cardiorespiratory fitness and associated loss of functional capacity.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».