Expression and Regulation of Metallothioneins in the Rat Epididymis
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Notice bibliographique
Résumé
Metallothioneins (MTs) are cytosolic proteins involved in cellular stress responses. The objectives of this study were to determine which epididymal cells express MTs, how they are regulated, and whether mRNA levels for 3 MT isoforms (MT I, MT II, and MT III) are modulated by heavy metals. MT expression was noted mainly in basal cells of all epididymal regions but not in all basal cells of any given region. MT I mRNA levels were highest in the testis, followed by levels in the corpus, cauda epididymidis, liver (positive control), caput epididymidis, initial segment, seminal vesicles, and ventral prostate. MT II mRNA levels were also highest in testis, followed by levels in the cauda, corpus, liver, caput, and initial segment, but they were undetectable in the seminal vesicles and ventral prostate. MT III mRNA levels were highest in the caput followed by testis and initial segment. Orchidectomy and orchidectomy with testosterone replacement experiments showed that immunoreactive MT in all epididymal segments was androgen dependent. Epididymal MT I mRNA levels were dependent on androgens in all segments except the corpus. MT II mRNA levels were androgen dependent only in the initial segment and corpus. MT III mRNA levels in the initial segment were not altered by orchidectomy but increased significantly in testosterone-treated rats. In the caput, MT III mRNA levels decreased following orchidectomy, but control levels were maintained by testosterone. In cadmium-injected rats, MT I mRNA levels were significantly increased in the testis and initial segment, but there were no effects in the liver and other epididymal regions. MT II mRNA levels were increased by more than eightfold in the liver and by three- to fourfold in the initial segment and caput. In the corpus, MT II mRNA levels were decreased by cadmium treatment. MT III mRNA levels were unaltered by cadmium treatment. In conclusion, all 3 MT transcripts are present in high abundance in the epididymis. Furthermore, MT is expressed mainly in basal cells with regulation by testosterone. Heavy metal induction appears to affect the proximal regions of the epididymis.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle