Race is a risk factor for calcinosis in patients with JDM – early results from the CARRAnet registry study
Notice bibliographique
Résumé
Children with juvenile dermatomyositis (JDM) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry study were included in this analysis. Race and ethnicity were self-reported. Subjects with current or past calcinosis were identified, and bi-variable associations between clinical variables and calcinosis were evaluated by Chi-square test, Fisher exact test, two-sample t-test, or Wilcoxon Rank Sum test as appropriate. A multivariable stepwise logistic regression model was run that included variables that were significantly associated in the bi-variable analysis, defined by P <0.1. All statistical analyses were conducted using JMP Stats version 8.0 (SAS Institute, Cary, NC). Prior to December 28, 2010, 102 subjects meeting modified Bohan and Peter criteria for JDM were enrolled from 23 U.S. sites. Fifteen subjects were excluded due to lack of data regarding calcinosis or race. Ten of the remaining 87 patients had a history of calcinosis. Potential predictors of calcinosis identified a priori included race, ethnicity, sex, ANA status, age, age of onset, duration of disease, and time to rheumatologic care. Bi-variable analyses revealed a significant association between calcinosis and African American (AA) race ( P =0.029), disease duration ( P =0.005), absence of antinuclear antibodies ( P =0.024), and male gender ( P =0.037) (Table 1 ). Analyzing these four variables in a multiple stepwise logistic regression model revealed that AA ancestry was the most significant predictor of calcinosis (OR [95% CI] 5.8 [1.3, 24.8] P =0.019). When demographic variables and outcome assessments were compared between AA patients and non-AA patients, only CHAQ scores were statistically significantly different in AA patients (mean (±SD), 0.54 (±0.51) vs. 0.29 (±0.52) in non-AA patients [ P = 0.033]). Children with JDM of African American ancestry have increased odds of developing calcinosis, even after controlling for duration of disease and time to rheumatologic care. Male gender, negative ANA status, and disease duration were associated with calcinosis in bi-variable analysis, however, these variables were limited by incomplete data capture, which may have affected the results of the multi-variable regression model. Analysis of a larger more complete cohort is needed to confirm these observations.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».